A developmental systems perspective on epistasis: computational exploration of mutational interactions in model developmental regulatory networks.

ABSTRACT: The way in which the information contained in genotypes is translated into complex phenotypic traits (i.e. embryonic expression patterns) depends on its decoding by a multilayered hierarchy of biomolecular systems (regulatory networks). Each layer of this hierarchy displays its own regulatory schemes (i.e. operational rules such as +/- feedback) and associated control parameters, resulting in characteristic variational constraints. This process can be conceptualized as a mapping issue, and in the context of highly-dimensional genotype-phenotype mappings (GPMs) epistatic events have been shown to be ubiquitous, manifested in non-linear correspondences between changes in the genotype and their phenotypic effects. In this study I concentrate on epistatic phenomena pervading levels of biologic

SUBMITTER: Gutierrez J 

PROVIDER: S-EPMC2734181 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature