Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brain.

ABSTRACT:

Objective

HIV enters the brain soon after infection causing neuronal damage and microglial/astrocyte dysfunction leading to neuropsychological impairment. We examined the impact of HIV on resting cerebral blood flow (rCBF) within the lenticular nuclei (LN) and visual cortex (VC).

Methods

This cross-sectional study used arterial spin labeling MRI (ASL-MRI) to measure rCBF within 33 HIV+ and 26 HIV- subjects. Nonparametric Wilcoxon rank sum test assessed rCBF differences due to HIV serostatus. Classification and regression tree (CART) analysis determined optimal rCBF cutoffs for differentiating HIV serostatus. The effects of neuropsychological impairment and infection duration on rCBF were evaluated.

Results

rCBF within the LN and VC were significantly reduced for HIV+

SUBMITTER: Ances BM 

PROVIDER: S-EPMC2734291 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature