Functional disturbances within frontostriatal circuits across multiple childhood psychopathologies.

ABSTRACT:

Objective

Neuroimaging studies of healthy individuals inform us about the normative maturation of the frontostriatal circuits that subserve self-regulatory control processes. Findings from these studies can be used as a reference frame against which to compare the aberrant development of these processes in individuals across a wide range of childhood psychopathologies.

Method

The authors reviewed extensive neuroimaging evidence for the presence of abnormalities in frontostriatal circuits in children and adults with Tourette's syndrome and obsessive-compulsive disorder (OCD) as well as a more limited number of imaging studies of adolescents and adults with anorexia nervosa or bulimia nervosa that, together, implicate dysregulation of frontostriatal control systems in the path

SUBMITTER: Marsh R 

PROVIDER: S-EPMC2734479 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature