Declined neural efficiency in cognitively stable human immunodeficiency virus patients.

ABSTRACT:

Objective

To determine whether brain activation changes in clinically and neurocognitively normal human immunodeficiency virus (HIV)-infected and in HIV-seronegative control (SN) participants over a 1-year period.

Methods

Functional magnetic resonance imaging (fMRI) was performed in 32 SN and 31 HIV patients (all with stable combination antiretroviral treatment) at baseline and after 1 year. Each participant performed a set of visual attention tasks with increasing attentional load (from tracking two, three, or four balls). All HIV and SN participants had normal neuropsychological function at both examinations.

Results

Over 1 year, HIV patients showed no change in their neurocognitive status or in task performance during fMRI. However, HIV patients showed significant

SUBMITTER: Ernst T 

PROVIDER: S-EPMC2734503 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature