Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study.

ABSTRACT:

Background

Mounting evidence indicates that HLA-mediated HIV evolution follows highly stereotypic pathways that result in HLA-associated footprints in HIV at the population level. However, it is not known whether characteristic HLA frequency distributions in different populations have resulted in additional unique footprints.

Methods

The phylogenetic dependency network model was applied to assess HLA-mediated evolution in datasets of HIV pol sequences from free plasma viruses and peripheral blood mononuclear cell (PBMC)-integrated proviruses in an immunogenetically unique cohort of Mexican individuals. Our data were compared with data from the IHAC cohort, a large multi-center cohort of individuals from Canada, Australia and the USA.

Results

Forty three different HLA-

SUBMITTER: Avila-Rios S 

PROVIDER: S-EPMC2734549 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature