Calculation of the relative metastabilities of proteins in subcellular compartments of Saccharomyces cerevisiae.

ABSTRACT:

Background

Protein subcellular localization and differences in oxidation state between subcellular compartments are two well-studied features of the the cellular organization of S. cerevisiae (yeast). Theories about the origin of subcellular organization are assisted by computational models that can integrate data from observations of compositional and chemical properties of the system. PRESENTATION AND IMPLICATIONS OF THE HYPOTHESIS: I adopt the hypothesis that the state of yeast subcellular organization is in a local energy minimum. This hypothesis implies that equilibrium thermodynamic models can yield predictions about the interdependence between populations of proteins and their subcellular chemical environments.

Testing the hypothesis

Three types of tests are proposed.

SUBMITTER: Dick JM 

PROVIDER: S-EPMC2734844 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature