Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.

ABSTRACT: The control of T-cell survival is of overwhelming importance for preventing leukemia and lymphoma. The present report demonstrates that the serine/threonine protein phosphatase PP4 regulates the survival of both leukemic T-cells and untransformed human peripheral blood T-cells, particularly after treatment with anti-leukemic drugs and other cytotoxic stimuli. PP4-induced apoptosis is mediated, at least in part, through de-phosphorylation of apoptosis regulator PEA-15, previously implicated in the control of leukemic cell survival. PP4 activity significantly affects the mutation rate in leukemic T-cells, indicating that PP4 dysfunction may be important in the development and progression of leukemia.

SUBMITTER: Mourtada-Maarabouni M 

PROVIDER: S-EPMC2734887 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature