The formin-homology protein SmDia interacts with the Src kinase SmTK and the GTPase SmRho1 in the gonads of Schistosoma mansoni.

ABSTRACT:

Background

Schistosomiasis (bilharzia) is a parasitic disease of worldwide significance affecting human and animals. As schistosome eggs are responsible for pathogenesis, the understanding of processes controlling gonad development might open new perspectives for intervention. The Src-like tyrosine-kinase SmTK3 of Schistosoma mansoni is expressed in the gonads, and its pharmacological inhibition reduces mitogenic activity and egg production in paired females in vitro. Since Src kinases are important signal transduction proteins it is of interest to unravel the signaling cascades SmTK3 is involved in to understand its cellular role in the gonads.

Methodology and results

Towards this end we established and screened a yeast two-hybrid (Y2H) cDNA library of adult S. mansoni with

SUBMITTER: Quack T 

PROVIDER: S-EPMC2734992 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature