Beta-amyloid burden is not associated with rates of brain atrophy.

ABSTRACT:

Objective

To test the hypothesis that beta-amyloid (Abeta) burden is associated with rates of brain atrophy.

Methods

Forty-five subjects who had been prospectively studied, died, and had an autopsy diagnosis of low, intermediate, or high probability of Alzheimer's disease who had two volumetric head magnetic resonance imaging scans were identified. Compact and total (compact + diffuse) Abeta burden was measured using a computerized image analyzer with software program to detect the proportion of gray matter occupied by Abeta. Visual ratings of Abeta burden were also performed. The boundary shift integral was used to calculate change over time in whole-brain and ventricular volume. All boundary shift integral results were annualized by adjusting for scan interval. Demographic

SUBMITTER: Josephs KA 

PROVIDER: S-EPMC2735194 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature