Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.

ABSTRACT:

Background

Ventricular dysfunction (VnD) after primary coronary artery bypass grafting is associated with increased hospital stay and mortality. Natriuretic peptides have compensatory vasodilatory, natriuretic, and paracrine influences on myocardial failure and ischemia. The authors hypothesized that natriuretic peptide system gene variants independently predict risk of VnD after primary coronary artery bypass grafting.

Methods

A total of 1,164 patients undergoing primary coronary artery bypass grafting with cardiopulmonary bypass at two institutions were prospectively enrolled. After prospectively defined exclusions, 697 patients of European descent (76 with VnD) were analyzed. VnD was defined as need for at least 2 new inotropes and/or new mechanical ventricular support af

SUBMITTER: Fox AA 

PROVIDER: S-EPMC2735337 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature