Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light.

ABSTRACT: MicroRNAs provide a formidable tool not only in cancer research but also to investigate physiological mechanisms and to assess the effect of environmental exposures in healthy tissues. Collectively, cigarette smoke and sunlight have been estimated to account for 40% of all human cancers, and not only smoke but also, surprisingly, UV light induced genomic and postgenomic alterations in mouse lung. Here we evaluated by microarray the expression of 484 microRNAs in the lungs of CD-1 mice, including newborns, postweanling males and females, and their dams, either untreated or exposed to environmental cigarette smoke and/or UV-containing light. The results obtained highlighted age-related variations in microRNA profiles, especially during the weanling period, due to perinatal stress and postnat

SUBMITTER: Izzotti A 

PROVIDER: S-EPMC2735372 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature