Combined statin and niacin therapy remodels the high-density lipoprotein proteome.

ABSTRACT:

Background

Boosting low high-density lipoprotein (HDL) levels is a current strategy for preventing clinical events that result from cardiovascular disease. We previously showed that HDL(3) of subjects with coronary artery disease is enriched in apolipoprotein E and that the lipoprotein carries a distinct protein cargo. This observation suggests that altered protein composition might affect the antiatherogenic and antiinflammatory properties of HDL. We hypothesized that an intervention that increases HDL levels-combined statin and niacin therapy-might reverse these changes.

Methods and results

HDL(3) isolated from 6 coronary artery disease subjects before and 1 year after combination therapy was analyzed by liquid chromatography-Fourier transform-mass spectrometry. Alteration

SUBMITTER: Green PS 

PROVIDER: S-EPMC2735443 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature