Ontology highlight
ABSTRACT:
SUBMITTER: Ng TM
PROVIDER: S-EPMC2735481 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20090715 17
Accurate chromosome segregation depends on sister kinetochores making bioriented attachments to microtubules from opposite poles. An essential regulator of biorientation is the Ipl1/Aurora B protein kinase that destabilizes improper microtubule-kinetochore attachments. To identify additional biorientation pathways, we performed a systematic genetic analysis between the ipl1-321 allele and all nonessential budding yeast genes. One of the mutants, mcm21Delta, precociously separates pericentromeres ...[more]