In vivo monitoring of inflammation after cardiac and cerebral ischemia by fluorine magnetic resonance imaging.

ABSTRACT:

Background

In this study, we developed and validated a new approach for in vivo visualization of inflammatory processes by magnetic resonance imaging using biochemically inert nanoemulsions of perfluorocarbons (PFCs).

Methods and results

Local inflammation was provoked in 2 separate murine models of acute cardiac and cerebral ischemia, followed by intravenous injection of PFCs. Simultaneous acquisition of morphologically matching proton ((1)H) and fluorine ((19)F) images enabled an exact anatomic localization of PFCs after application. Repetitive (1)H/(19)F magnetic resonance imaging at 9.4 T revealed a time-dependent infiltration of injected PFCs into the border zone of infarcted areas in both injury models, and histology demonstrated a colocalization of PFCs with cells of

SUBMITTER: Flogel U 

PROVIDER: S-EPMC2735653 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature