Hydrogen sulfide mediates cardioprotection through Nrf2 signaling.

ABSTRACT:

Rationale

The recent emergence of hydrogen sulfide (H(2)S) as a potent cardioprotective signaling molecule necessitates the elucidation of its cytoprotective mechanisms.

Objective

The present study evaluated potential mechanisms of H(2)S-mediated cardioprotection using an in vivo model of pharmacological preconditioning.

Methods and results

H(2)S (100 microg/kg) or vehicle was administered to mice via an intravenous injection 24 hours before myocardial ischemia. Treated and untreated mice were then subjected to 45 minutes of myocardial ischemia followed by reperfusion for up to 24 hours, during which time the extent of myocardial infarction was evaluated, circulating troponin I levels were measured, and the degree of oxidative stress was evaluated. In separate studies

SUBMITTER: Calvert JW 

PROVIDER: S-EPMC2735849 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature