Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.

ABSTRACT: Genetic instability, which leads to an accumulation of various genetic abnormalities, has been considered an essential component of the human neoplasic transformation process. However, the molecular basis of genomic instability during tumorigenesis remains incompletely understood. Growing evidence indicates that checkpoint with forkhead and ring finger domains (CHFR), a recently identified mitotic checkpoint protein, plays an important role in maintaining chromosome integrity and functions as a tumor suppressor. In this study, we used high-throughput technology to conduct gene expression profiling of human colon cancers and found that loss of CHFR expression frequently occurred in colon cancers with high microsatellite instability (MSI-H). Downregulation of CHFR expression was closely asso

SUBMITTER: Fu Z 

PROVIDER: S-EPMC2735912 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature