Association between a prognostic gene signature and functional gene sets.

ABSTRACT:

Background

The development of expression-based gene signatures for predicting prognosis or class membership is a popular and challenging task. Besides their stringent validation, signatures need a functional interpretation and must be placed in a biological context. Popular tools such as Gene Set Enrichment have drawbacks because they are restricted to annotated genes and are unable to capture the information hidden in the signature's non-annotated genes.

Methodology

We propose concepts to relate a signature with functional gene sets like pathways or Gene Ontology categories. The connection between single signature genes and a specific pathway is explored by hierarchical variable selection and gene association networks. The risk score derived from an individual patient's sig

SUBMITTER: Hummel M 

PROVIDER: S-EPMC2735947 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature