Thermal intramolecular [4 + 2] cycloadditions of allenamides: a stereoselective tandem propargyl amide isomerization-cycloaddition.

ABSTRACT: A stereoselective intramolecular normal demand [4 + 2] cycloaddition of allenamides under thermal conditions without metal assistance is described. This work led to the development of a stereoselective tandem propargyl amide-isomerization-[4 + 2] cycloaddition sequence amenable for rapid assembly of complex nitrogen heterocycles.

SUBMITTER: Lohse AG 

PROVIDER: S-EPMC2736324 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature