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Hydrogen sulfide-induced hypometabolism prevents renal ischemia/reperfusion injury.

ABSTRACT: Hydrogen sulfide (H(2)S) can induce a hypometabolic, hibernation-like state in mammals when given in subtoxic concentrations. Pharmacologically reducing the demand for oxygen is a promising strategy to minimize unavoidable hypoxia-induced injury such as ischemia/reperfusion injury during renal transplantation. Here we show that H(2)S reduces metabolism in vivo, ex vivo, and in vitro. Furthermore, we demonstrate the beneficial effects of H(2)S-induced hypometabolism in a model of bilateral renal ischemia/reperfusion injury using three different treatment strategies. The results demonstrate striking protective effects on survival, renal function, apoptosis, and inflammation. A hypometabolic state induced by H(2)S might have therapeutic potential to protect kidneys that suffer from hypoxia.

SUBMITTER: Bos EM 

PROVIDER: S-EPMC2736772 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Hydrogen sulfide-induced hypometabolism prevents renal ischemia/reperfusion injury.

Bos Eelke M EM   Leuvenink Henri G D HG   Snijder Pauline M PM   Kloosterhuis Niels J NJ   Hillebrands Jan-Luuk JL   Leemans Jaklien C JC   Florquin Sandrine S   van Goor Harry H  

Journal of the American Society of Nephrology : JASN 20090723 9

Hydrogen sulfide (H(2)S) can induce a hypometabolic, hibernation-like state in mammals when given in subtoxic concentrations. Pharmacologically reducing the demand for oxygen is a promising strategy to minimize unavoidable hypoxia-induced injury such as ischemia/reperfusion injury during renal transplantation. Here we show that H(2)S reduces metabolism in vivo, ex vivo, and in vitro. Furthermore, we demonstrate the beneficial effects of H(2)S-induced hypometabolism in a model of bilateral renal  ...[more]