Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer.

ABSTRACT:

Background

Angiogenesis and lymphangiogenesis are considered to play key roles in tumour growth, progression and metastasis. However, targeting tumour angiogenesis in clinical trials showed only modest efficacy. We therefore scrutinised the concept of tumour angiogenesis and lymphangiogenesis by analysing the expression of crucial markers involved in these processes in primary breast cancer.

Methods

We analysed the expression of angiogenic, lymphangiogenic or antiangiogenic factors, their respective receptors and specific markers for endothelial and lymphendothelial cells by quantitative real-time RT-PCR in primary breast cancer and compared the expression profiles to non-cancerous, tumour-adjacent tissues and breast tissues from healthy women.

Results

We found decrea

SUBMITTER: Boneberg EM 

PROVIDER: S-EPMC2736814 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature