Global control of cell-cycle transcription by coupled CDK and network oscillators.

ABSTRACT: A significant fraction of the Saccharomyces cerevisiae genome is transcribed periodically during the cell division cycle, indicating that properly timed gene expression is important for regulating cell-cycle events. Genomic analyses of the localization and expression dynamics of transcription factors suggest that a network of sequentially expressed transcription factors could control the temporal programme of transcription during the cell cycle. However, directed studies interrogating small numbers of genes indicate that their periodic transcription is governed by the activity of cyclin-dependent kinases (CDKs). To determine the extent to which the global cell-cycle transcription programme is controlled by cyclin-CDK complexes, we examined genome-wide transcription dynamics in budding yeas

SUBMITTER: Orlando DA 

PROVIDER: S-EPMC2736871 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature