Mitochondrial dysregulation and oxidative stress in patients with chronic kidney disease.

ABSTRACT:

Background

Chronic renal disease (CKD) is characterized by complex changes in cell metabolism leading to an increased production of oxygen radicals, that, in turn has been suggested to play a key role in numerous clinical complications of this pathological condition. Several reports have focused on the identification of biological elements involved in the development of systemic biochemical alterations in CKD, but this abundant literature results fragmented and not exhaustive.

Results

To better define the cellular machinery associated to this condition, we employed a high-throughput genomic approach based on a whole transcriptomic analysis associated with classical molecular methodologies. The genomic screening of peripheral blood mononuclear cells revealed that 44 genes wer

SUBMITTER: Granata S 

PROVIDER: S-EPMC2737002 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature