Chorionic gonadotropin beta-gene variants are associated with recurrent miscarriage in two European populations.

ABSTRACT:

Context

The incidence of recurrent miscarriage (RM) (>or=3 consecutive pregnancy losses) is estimated as 1-2% in fertile couples. Familial clustering of RM has suggested the contribution of a genetic component.

Objective

A low level of human chorionic gonadotropin (HCG) in maternal serum during the first trimester of the pregnancy is a clinically accepted risk factor for miscarriage. We sought to study whether variation in chorionic gonadotropin beta-subunit genes (CGBs) expressed in placenta may contribute to the risk of RM.

Design

Resequencing of CGB5 and CGB8, the two most actively transcribed loci of the four HCG beta-duplicate genes, was performed.

Setting

A case-control study involving two sample sets, from Estonia (n = 194) and Finland (n = 185), was per

SUBMITTER: Rull K 

PROVIDER: S-EPMC2737125 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature