Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans development.

ABSTRACT:

Background

The nematode Caenorhabditis elegans is being assessed as an alternative model organism as part of an interagency effort to develop better means to test potentially toxic substances. As part of this effort, assays that use the COPAS Biosort flow sorting technology to record optical measurements (time of flight (TOF) and extinction (EXT)) of individual nematodes under various chemical exposure conditions are being developed. A mathematical model has been created that uses Biosort data to quantitatively and qualitatively describe C. elegans growth, and link changes in growth rates to biological events. Chlorpyrifos, an organophosphate pesticide known to cause developmental delays and malformations in mammals, was used as a model toxicant to test the applicability of the gro

SUBMITTER: Boyd WA 

PROVIDER: S-EPMC2737145 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature