Profile of estrogen-responsive genes in an estrogen-specific mammary gland outgrowth model.

ABSTRACT: Both ovarian and pituitary hormones are required for the pubertal development of the mouse mammary gland. Estradiol directs ductal elongation and branching, while progesterone leads to tertiary branching and alveolar development. The purpose of this investigation was to identify estrogen-responsive genes associated with pubertal ductal growth in the mouse mammary gland in the absence of other ovarian hormones and at different stages of development. We hypothesized that the estrogen-induced genes and their associated functions at early stages of ductal elongation would be distinct from those induced after significant ductal elongation had occurred. Therefore, ovariectomized prepubertal mice were exposed to 17beta-estradiol from two to 28 days, and mammary gland global gene expression analyz

SUBMITTER: Deroo BJ 

PROVIDER: S-EPMC2737274 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature