Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins.

ABSTRACT: Lantibiotics are ribosomally synthesized peptide antimicrobials which contain considerable posttranslational modifications. Given their usually broad host range and their highly stable structures, there have been renewed attempts to identify and characterize novel members of the lantibiotic family in recent years. The increasing availability of bacterial genome sequences means that in addition to traditional microbiological approaches, in silico screening strategies may now be employed to the same end. Taking advantage of the highly conserved nature of lantibiotic biosynthetic enzymes, we screened publicly available microbial genome sequences for genes encoding LanM proteins, which are required for the posttranslational modification of type 2 lantibiotics. By using this approach, 89 LanM h

SUBMITTER: Begley M 

PROVIDER: S-EPMC2737927 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature