Identification of specific and universal virulence factors in Burkholderia cenocepacia strains by using multiple infection hosts.

ABSTRACT: Over the past few decades, strains of the Burkholderia cepacia complex have emerged as important pathogens for patients suffering from cystic fibrosis. Identification of virulence factors and assessment of the pathogenic potential of Burkholderia strains have increased the need for appropriate infection models. In previous studies, different infection hosts, including mammals, nematodes, insects, and plants, have been used. At present, however, the extent to which the virulence factors required to infect different hosts overlap is not known. The aim of this study was to analyze the roles of various virulence factors of two closely related Burkholderia cenocepacia strains, H111 and the epidemic strain K56-2, in a multihost pathogenesis system using four different model organisms, namely, Ca

SUBMITTER: Uehlinger S 

PROVIDER: S-EPMC2738042 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature