Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections.

ABSTRACT: Staphylococcus aureus can establish chronic infections on implanted medical devices due to its capacity to form biofilms. Analysis of the factors that assemble cells into a biofilm has revealed the occurrence of strains that produce either a polysaccharide intercellular adhesin/poly-N-acetylglucosamine (PIA/PNAG) exopolysaccharide- or a protein-dependent biofilm. Examination of the influence of matrix nature on the biofilm capacities of embedded bacteria has remained elusive, because a natural strain that readily converts between a polysaccharide- and a protein-based biofilm has not been studied. Here, we have investigated the clinical methicillin (meticillin)-resistant Staphylococcus aureus strain 132, which is able to alternate between a proteinaceous and an exopolysaccharidic biofilm ma

SUBMITTER: Vergara-Irigaray M 

PROVIDER: S-EPMC2738049 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature