Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.

ABSTRACT:

Background

Up until recently the only available experimental (high resolution) structure of a G-protein-coupled receptor (GPCR) was that of bovine rhodopsin. In the past few years the determination of GPCR structures has accelerated with three new receptors, as well as squid rhodopsin, being successfully crystallized. All share a common molecular architecture of seven transmembrane helices and can therefore serve as templates for building molecular models of homologous GPCRs. However, despite the common general architecture of these structures key differences do exist between them. The choice of which experimental GPCR structure(s) to use for building a comparative model of a particular GPCR is unclear and without detailed structural and sequence analyses, could be arbitrary. The a

SUBMITTER: Worth CL 

PROVIDER: S-EPMC2738427 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature