Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children.

ABSTRACT:

Background

Because asthma has been associated with exercise and ozone exposure, an association likely mediated by oxidative stress, we hypothesised that glutathione-S-transferase (GST)P1, GSTM1, exercise and ozone exposure have interrelated effects on the pathogenesis of asthma.

Methods

Associations of the well characterised null variant of GSTM1 and four single nucleotide polymorphisms (SNPs) that characterised common variation in the GSTP1 locus with new onset asthma in a cohort of 1610 school children were examined. Children's exercise and ozone exposure were classified using participation in team sports and community annual average ozone levels, respectively.

Results

A two SNP model involving putatively functional variants (rs6591255, rs1695 (Ile105Va)) best captu

SUBMITTER: Islam T 

PROVIDER: S-EPMC2738935 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature