European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus.

ABSTRACT:

Objective

To determine whether genetic substructure in European-derived populations is associated with specific manifestations of systemic lupus erythematosus (SLE), including mucocutaneous phenotypes, autoantibody production, and renal disease.

Methods

SLE patients of European descent (n=1,754) from 8 case collections were genotyped for >1,400 ancestry informative markers that define a north-south gradient of European substructure. Using the Structure program, each SLE patient was characterized in terms of percent Northern (versus percent Southern) European ancestry based on these genetic markers. Nonparametric methods, including tests for trend, were used to identify associations between Northern European ancestry and specific SLE manifestations.

Results

In multivar

SUBMITTER: Chung SA 

PROVIDER: S-EPMC2739103 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature