Does negative auto-regulation increase gene duplicability?

ABSTRACT:

Background

A prerequisite for a duplication to spread through and persist in a given population is retaining expression of both gene copies. Yet changing a gene's dosage is frequently detrimental to fitness. Consequently, dosage-sensitive genes are less likely to duplicate. However, in cases where the level of gene product is controlled, via negative feedback, by its own abundance, an increase in gene copy number can in principle be decoupled from an increase in protein while both copies remain expressed. Using data from the transcriptional networks of E. coli and S. cerevisiae, we test the hypothesis that genes under negative auto-regulation show enhanced duplicability.

Results

Controlling for several known correlates of duplicability, we find no statistically significant s

SUBMITTER: Warnecke T 

PROVIDER: S-EPMC2739200 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature