Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma.

ABSTRACT:

Background

Recent studies have demonstrated that a molecular subtype of glioblastoma is characterized by overexpression of extracellular matrix (ECM)/mesenchymal components and shorter survival. Specifically, gene expression profiling studies revealed that matrix gla protein (MGP), whose function has traditionally been linked to inhibition of calcification of arteries and cartilage, is overexpressed in glioblastomas and associated with worse outcome.

Methods

In order to analyze the role of MGP in glioblastomas, we performed expression, migration and proliferation studies.

Results

Real-time PCR and ELISA assays confirmed overexpression of MGP in glioblastoma biopsy specimens and cell lines at mRNA and protein levels as compared to normal brain tissue. Immunohistochemis

SUBMITTER: Mertsch S 

PROVIDER: S-EPMC2739228 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature