A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability.

ABSTRACT:

Objective

Platelet endothelial aggregation receptor-1 (PEAR1) is a recently identified platelet transmembrane protein that becomes activated by platelet contact. We looked for novel genetic variants in PEAR1 and studied their association with agonist-induced native platelet aggregation and with the inhibitory effect of aspirin on platelets.

Methods and results

We genotyped PEAR1 for 10 single nucleotide polymorphisms (SNPs), selected for optimal gene coverage at a density of 4 kb, in 1486 apparently healthy individuals from two generations of families with premature CAD. Subjects had a mean age of 45 years; 62% were white and 38% black. Platelet aggregation to collagen, epinephrine, and ADP was measured in platelet rich plasma, at baseline and after 2 weeks of aspirin (ASA,

SUBMITTER: Herrera-Galeano JE 

PROVIDER: S-EPMC2739240 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature