Gene expression profiling in cells with enhanced gamma-secretase activity.

ABSTRACT:

Background

Processing by gamma-secretase of many type-I membrane protein substrates triggers signaling cascades by releasing intracellular domains (ICDs) that, following nuclear translocation, modulate the transcription of different genes regulating a diverse array of cellular and biological processes. Because the list of gamma-secretase substrates is growing quickly and this enzyme is a cancer and Alzheimer's disease therapeutic target, the mapping of gamma-secretase activity susceptible gene transcription is important for sharpening our view of specific affected genes, molecular functions and biological pathways.

Methodology/principal findings

To identify genes and molecular functions transcriptionally affected by gamma-secretase activity, the cellular transcriptomes of Ch

SUBMITTER: Magold AI 

PROVIDER: S-EPMC2739295 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature