The Modular Organization of Protein Interactions in Escherichia coli.

ABSTRACT: Escherichia coli serves as an excellent model for the study of fundamental cellular processes such as metabolism, signalling and gene expression. Understanding the function and organization of proteins within these processes is an important step towards a 'systems' view of E. coli. Integrating experimental and computational interaction data, we present a reliable network of 3,989 functional interactions between 1,941 E. coli proteins ( approximately 45% of its proteome). These were combined with a recently generated set of 3,888 high-quality physical interactions between 918 proteins and clustered to reveal 316 discrete modules. In addition to known protein complexes (e.g., RNA and DNA polymerases), we identified modules that represent biochemical pathways (e.g., nitrate regulation and cel

SUBMITTER: Peregrin-Alvarez JM 

PROVIDER: S-EPMC2739439 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature