NMR and molecular modelling studies on the interaction of fluconazole with beta-cyclodextrin.

ABSTRACT:

Background

Fluconazole (FLZ) is a synthetic, bistriazole antifungal agent, effective in treating superficial and systemic infections caused by Candida species. Major challenges in formulating this drug for clinical applications include solubility enhancement and improving stability in biological systems. Cyclodextrins (CDs) are chiral, truncated cone shaped macrocyles, and can easily encapsulate fluconazole inside their hydrophobic cavity. NMR spectroscopy has been recognized as an important tool for the interaction study of cyclodextrin and pharmaceutical compounds in solution state.

Results

Inclusion complex of fluconazole with beta-cyclodextrins (beta-CD) were investigated by applying NMR and molecular modelling methods. The 1:1 stoichiometry of FLZ:beta-CD complex was de

SUBMITTER: Upadhyay SK 

PROVIDER: S-EPMC2739844 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature