Double-blind, randomized, comparative study of Meditoxin versus Botox in the treatment of essential blepharospasm.

ABSTRACT:

Purpose

To compare the efficacies and safeties of Meditoxin (Medy-Tox, Korea) and Botox in the treatment of essential blepharospasm.

Methods

We performed a double-blind, randomized, comparative trial comparing Meditoxin and Botox for treatment of blepharospasm in 60 patients from the intention-to-treat (ITT) population and 52 patients from the per-protocol (PP) population. We analyzed the improvements in severity of spasm (SS) at four weeks post-injection as a primary efficacy outcome. Changes in eyelid closing force (CF) and functional visual status (FVS) after injection were analyzed for secondary efficacy outcomes, and adverse effects were demonstrated for the safety evaluation.

Results

Improvement in SS was noted in 90.3% of the Meditoxin group and 86.2% of the Bo

SUBMITTER: Yoon JS 

PROVIDER: S-EPMC2739960 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature