Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol.

ABSTRACT: Recent studies have indicated that direct intestinal secretion of plasma cholesterol significantly contributes to fecal neutral sterol loss in mice. The physiological relevance of this novel route, which represents a part of the reverse cholesterol transport pathway, has not been directly established in vivo as yet. We have developed a method to quantify the fractional and absolute contributions of several cholesterol fluxes to total fecal neutral sterol loss in vivo in mice, by assessing the kinetics of orally and intravenously administered stable isotopically labeled cholesterol combined with an isotopic approach to assess the fate of de novo synthesized cholesterol. Our results show that trans-intestinal cholesterol excretion significantly contributes to removal of blood-derived free ch

SUBMITTER: van der Veen JN 

PROVIDER: S-EPMC2740545 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature