Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2).

ABSTRACT:

Background

A 776C-->G variant (dbSNP ID: rs1801198) in the transcobalamin gene (TCN2; MIM# 275350) decreases the cellular and plasma concentration of transcobalamin and thereby influences the cellular availability of vitamin B(12).

Objective

To evaluate the worldwide prevalence of this variant and its association with homocysteine plasma level.

Methods

The study was performed in 1433 apparently healthy subjects, including Afro-Americans and Afro-Africans and in 251 Afro-Africans participants with severe malaria.

Results

The frequencies of the 776G allele were the highest in China (0.607; 95% CI 0.554 to 0.659), low in West Africa (Bénin and Togo, 0.178; 0.154 to 0.206), and intermediate in France (0.445; 0.408 to 0.481), Italy (0.352; 0.299 to 0.409), Morocco (

SUBMITTER: Gueant JL 

PROVIDER: S-EPMC2740879 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature