Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC2740991 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Liu Cheng C Xu Pinglong P Lamouille Samy S Xu Jian J Derynck Rik R
Molecular cell 20090701 1
Regulating TGF-beta receptor presentation provides an avenue to alter a cell's responsiveness to TGF-beta. We report that activation of the Erk MAP kinase pathway decreases the TGF-beta-induced Smad3 activation due to decreased cell surface levels of the type I receptor TbetaRI, but not the type II receptor. Inhibition of TACE activity or expression enhanced the cell surface TbetaRI levels and TGF-beta-induced Smad3 and Akt activation. Accordingly, silencing TACE expression in cancer cells enhan ...[more]