A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networks.

ABSTRACT: A detailed computational model is developed to simulate oxygen transport from a three-dimensional (3D) microvascular network to the surrounding tissue in the presence of hemoglobin-based oxygen carriers. The model accounts for nonlinear O(2) consumption, myoglobin-facilitated diffusion and nonlinear oxyhemoglobin dissociation in the RBCs and plasma. It also includes a detailed description of intravascular resistance to O(2) transport and is capable of incorporating realistic 3D microvascular network geometries. Simulations in this study were performed using a computer-generated microvascular architecture that mimics morphometric parameters for the hamster cheek pouch retractor muscle. Theoretical results are presented next to corresponding experimental data. Phosphorescence quenching micro

SUBMITTER: Tsoukias NM 

PROVIDER: S-EPMC2741314 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature