The chromosome 7q region association with rheumatoid arthritis in females in a British population is not replicated in a North American case-control series.

ABSTRACT:

Objective

The single-nucleotide polymorphism (SNP) rs11761231 on chromosome 7q has been reported to be sexually dimorphic marker for rheumatoid arthritis (RA) susceptibility in a British population. We sought to replicate this finding and to better characterize susceptibility alleles in the region in a North American population.

Methods

DNA from 2 North American collections of RA patients and controls (1,605 cases and 2,640 controls) was genotyped for rs11761231 and 16 additional chromosome 7q tag SNPs using Sequenom iPlex assays. Association tests were performed for each collection and also separately, contrasting male cases with male controls and female cases with female controls. Principal components analysis (EigenStrat) was used to determine association with RA before a

SUBMITTER: Korman BD 

PROVIDER: S-EPMC2741408 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature