Molecular mechanisms of tungstate-induced pancreatic plasticity: a transcriptomics approach.

ABSTRACT:

Background

Sodium tungstate is known to be an effective anti-diabetic agent, able to increase beta cell mass in animal models of diabetes, although the molecular mechanisms of this treatment and the genes that control pancreas plasticity are yet to be identified. Using a transcriptomics approach, the aim of the study is to unravel the molecular mechanisms which participate in the recovery of exocrine and endocrine function of streptozotocin (STZ) diabetic rats treated with tungstate, determining the hyperglycemia contribution and the direct effect of tungstate.

Results

Streptozotocin (STZ)-diabetic rats were treated orally with tungstate for five weeks. Treated (STZ)-diabetic rats showed a partial recovery of exocrine and endocrine function, with lower glycemia, increased in

SUBMITTER: Altirriba J 

PROVIDER: S-EPMC2741493 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature