Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways.

ABSTRACT: One aim for an HIV vaccine is to elicit neutralizing antibodies (Nab) that can limit replication of genetically diverse viruses and prevent establishment of a new infection. Thus, identifying the strengths and weaknesses of Nab during the early stages of natural infection could prove useful in achieving this goal. Here we demonstrate that viral escape readily occurred despite the development of high titer autologous Nab in two subjects with acute/early subtype C infection. To provide a detailed portrayal of the escape pathways, Nab resistant variants identified at multiple time points were used to create a series of envelope (Env) glycoprotein chimeras and mutants within the background of a corresponding newly transmitted Env. In one subject, Nab escape was driven predominantly by changes

SUBMITTER: Rong R 

PROVIDER: S-EPMC2741593 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature