Thyroid hormone-related regulation of gene expression in human fatty liver.

ABSTRACT:

Context

Fatty liver is an important complication of obesity; however, regulatory mechanisms mediating altered gene expression patterns have not been identified.

Objective

The aim of the study was to identify novel transcriptional changes in human liver that could contribute to hepatic lipid accumulation and associated insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis.

Design

We evaluated gene expression in surgical liver biopsies from 13 obese (nine with type 2 diabetes) and five control subjects using Affymetrix U133A microarrays. PCR validation was performed in liver biopsies using an additional 16 subjects. We also tested thyroid hormone responses in mice fed chow or high-fat diet.

Setting

Recruitment was performed in an academic medical

SUBMITTER: Pihlajamaki J 

PROVIDER: S-EPMC2741713 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature