Association of plasma leptin concentrations with adiposity measurements in rural Chinese adolescents.

ABSTRACT:

Context

There is evidence that leptin is involved in the etiology of obesity-related cardiovascular disease in adults. This raises the question of whether leptin levels in adolescence are indicative of adiposity-related cardiovascular risk.

Objective

This study investigated gender-specific patterns of plasma leptin during adolescence, assessed which adiposity measurements are most strongly associated with plasma leptin, and estimated to what degree leptin-adiposity associations are influenced by genetic factors.

Methods

Plasma leptin concentrations were determined using a sandwich immunoassay. Associations between plasma leptin and several adiposity measurements were examined using generalized estimating equations. Genetic contribution to leptin-adiposity association

SUBMITTER: Zhang S 

PROVIDER: S-EPMC2741718 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature