Effects of L-isoleucine and L-valine on hot flushes and serum homocysteine: a randomized controlled trial.

ABSTRACT:

Objective

To investigate whether L-isoleucine was effective in the treatment of hot flushes and whether L-isoleucine, L-valine, or the combination of both amino acids reduced fasting serum homocysteine.

Methods

After a 1-week baseline period, 100 postmenopausal women experiencing at least five moderate-severe hot flushes per day were randomized with equal probability to one of four groups (phase 1/phase 2): placebo/L-valine, placebo/L-valine and L-isoleucine, L-isoleucine/L-valine, and L-isoleucine/L-valine and L-isoleucine. Phase 1 was 12 weeks long, and phase 2 was 10 weeks long. Patients took five capsules by mouth, twice a day throughout the study, with each capsule containing 500 mg of compound. Data were obtained from daily hot flush diaries, fasting blood work, and se

SUBMITTER: Guttuso T 

PROVIDER: S-EPMC2742338 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature