Chromosome 6p22 locus associated with clinically aggressive neuroblastoma.

ABSTRACT:

Background

Neuroblastoma is a malignant condition of the developing sympathetic nervous system that most commonly affects young children and is often lethal. Its cause is not known.

Methods

We performed a genomewide association study by first genotyping blood DNA samples from 1032 patients with neuroblastoma and 2043 control subjects of European descent using the Illumina HumanHap550 BeadChip. Samples from three independent groups of patients with neuroblastoma (a total of 720 patients) and 2128 control subjects were then genotyped to replicate significant associations.

Results

We observed a significant association between neuroblastoma and the common minor alleles of three consecutive single-nucleotide polymorphisms (SNPs) at chromosome band 6p22 and containing the p

SUBMITTER: Maris JM 

PROVIDER: S-EPMC2742373 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature