Odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate.

ABSTRACT: The kidney and vasculature are intimately linked both functionally and during development, when nephric and blood/vascular progenitor cells occupy adjacent bands of mesoderm in zebrafish and frog embryos. Developmental mechanisms that underlie the differentiation of kidney versus blood/vascular lineages remain unknown. The odd skipped related1 (osr1) gene encodes a zinc-finger transcription factor that is expressed in the germ ring mesendoderm and subsequently in the endoderm and intermediate mesoderm, prior to the expression of definitive kidney or blood/vascular markers. Knockdown of osr1 in zebrafish embryos resulted in a complete, segment-specific loss of anterior kidney progenitors and a compensatory increase in the number of angioblast cells in the same trunk region. Histology reveal

SUBMITTER: Mudumana SP 

PROVIDER: S-EPMC2742377 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature